Literature summary extracted from

Busek, P.; Balaziova, E.; Matrasova, I.; Hilser, M.; Tomas, R.; Syrucek, M.; Zemanova, Z.; Krepela, E.; Belacek, J.; Sedo, A.
Fibroblast activation protein alpha is expressed by transformed and stromal cells and is associated with mesenchymal features in glioblastoma (2016), Tumour Biol., 37, 13961-13971 .

Application

EC Number	Application	Comment	Organism
3.4.21.B28	medicine	the limited expression of the enzyme in healthy tissues together with its presence in both transformed and stromal cells suggests that it may be a candidate target for specific delivery of therapeutic agents in glioblastoma	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.B28	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.B28	glioma cell	increased enzyme expression in a subgroup of high-grade gliomas. The enzyme is expressed by several constituents of the glioblastoma microenvironment, including stromal non-malignant mesenchymal cells recruited to and/or activated in response to glioma growth	Homo sapiens	-
3.4.21.B28	mesenchymal cell	the enzyme is expressed by several constituents of the glioblastoma microenvironment, including stromal non-malignant mesenchymal cells recruited to and/or activated in response to glioma growth	Homo sapiens	-

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Release 2023.1 (January 2023)